bosentan Fundamentals Explained
Ketoconazole Coadministration of bosentan one hundred twenty five mg 2 times day by day and ketoconazole, a strong CYP3A inhibitor, greater the plasma concentrations of bosentan by approximately 100% in normal volunteers. No dose adjustment of bosentan is essential, but greater consequences of bosentan need to be regarded.Bosentan and Ro forty eigh